Breaking the Script: The Rise of Antidepressant Drugs

The opioid crisis exposed how well-intentioned care, shaped by misaligned incentives, can cause widespread harm. A similar pattern is now emerging with antidepressants.

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INTRODUCTION

The opioid crisis has taught us the lesson that well-intentioned medicine, when paired with misaligned incentives, can produce devastating public health outcomes. What was introduced in the 1990s as revolutionary pain prescriptions, turned out to become a health epidemic catalyzed by large pharmaceutical companies selling a product in which there was direct knowledge that long-term usage led to difficulties in patients withdrawing. Prescribing physicians contributed to the epidemic not out of greed or malintent, but sympathy. A place of…

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